DSIP - 5mg Magnus

DSIP 5mg Magnus

DSIP is an abbreviation of Delta Sleep-Induce Peptide. It is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities.

Its amino acid sequence is Тrр-Аlа-Gly-Gly-Asp-Ala-Ser-Gly-Glu. However, it is the only neuropeptide in history whose gene is unknown, raising serious questions regarding the actual existence of this peptide in nature

Structure and interactions

DSIP is an amphiphilic peptide in nature. Its molecular weight is 850 Daltons. Its amino acid motif is N-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-C

It has been found in thehypothalamusin both free and bound forms. It found in thelimbic system and pituitary as well as various peripheral organs, tissue and body fluids. In the pituitary, it colocalizes with many peptides and nonpeptides mediators such as corticotropin-like intermediate peptide (CLIP) adrenocorticotrophic hormone (ACTH) melanocyte-stimulating hormone (MSH), Thyroid-stimulating hormone (TSH) and melanin-concentrating hormone (MCH). It is abundant in the gut secretory cells and in the pancreas where it co-localizes with glucagon.

In the brain, its action may be mediated by NMDA receptors. In another scientific study in the rats, acetyltransferase activates through a1 receptors by the stimulation of the delta sleep-inducing peptide. The place where DSIP is synthesized is unknown. It has been found to have a low molecular stability in the vitro, with half-life of only 15 minutes due to the action of a specific aminopeptidase like enzyme. Scientific has been suggested that in the human body it make complexes with carrier proteins  to prevent degradation, or exists as a component of a large precursor molecule, but as yet no structure or gene has been found for this precursors

All the Scientific evidence supports the current belief that it is regulated by glucocorticoids. Gimble et al. suggest that DSIP  interacts with components of MAPK cascade and is homologous to glucocorticoid---induced leucine zipper (GILZ). GlLZ can beinduce by Dexamethasone. It prevents Raf-1 activation, which inhibits phosphorylation and activation of ERK.

Function

Many roles for DSIP have been suggested following research carried out using peptide analogs with a greater molecular stability and through measuring DSIP like immunological 9( DSIP LI) response by injection DSIP antiserum and antibodies

Roles in endocrine regulation

•          Decreases basal corticotropin level and blocks its release.
•          Stimulates release of luteinizing hormone (LH).
•          Stimulates release of somatoliberin and somatotrophinsecretion and inhibits somatostatin secretion.
•          Can act as a stress limiting factor.
•          May have a direct or indirect effect on body temperature and alleviating hypothermia
•          Can normalize blood pressure and myocardial contraction.
•          There is also conflicting evidence as to its involvement in sleep patterns. Some studies suggest a link between DSIP and slow-wave sleep (SWS) promotion and suppression of paradoxical sleep, (PS) while some studies show no correlation. Stronger effects on sleep have been noted for the synthesized analogues of DSIP.
•          It may affect human lens epithelial cell function via the MAPK pathway, which is involved in cell proliferation, differentiation, motility, survival, and apoptosis

Roles in physiological processes

•          Can act as a stress limiting factor.
•          May have a direct or indirect effect on body temperature and alleviating hypothermia
•          Can normalize blood pressure and myocardial contraction.
•          There is also conflicting evidence as to its involvement in sleep patterns. Some studies suggest a link between DSIP and slow-wave sleep (SWS) promotion and suppression of paradoxical sleep, (PS) while some studies show no correlation. Stronger effects on sleep have been noted for the synthesized analogues of DSIP.
•          It may affect human lens epithelial cell function via the MAPK pathway, which is involved in cell proliferation, differentiation, motility, survival, and apoptosis.